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Frontolimbic Maturation in Adolescence
2013 - 2022
The period centers on frontolimbic maturation and emotion regulation development, evidenced by shifts in amygdala–prefrontal connectivity and involvement of the insula and anterior cingulate networks. Structural brain maturation, including cortical thinning and white matter development, provides the anatomical scaffolding for evolving cognitive-emotional abilities and risk-taking behaviors, with links to frontolimbic connectivity evolution. Resting-state and network-level approaches, along with methodological advances in large-scale data processing and motion/physiological confound correction, underpin robust investigations into development and psychopathology.
• Frontolimbic maturation and emotion regulation disruption in adolescence: converging evidence across functional connectivity shifts in amygdala–prefrontal circuits, insula, ACC, and related networks, underlying mood disorders and emotional processing changes [3], [2], [10], [12], [16], [9], [15], [19].
• Structural brain maturation (cortex thinning; white matter) as scaffolding for adolescent cognitive-emotional development and risk behaviours, including alcohol use, with links to frontolimbic connectivity and overall brain maturation [8], [5], [11], [13].
• Resting-state and network-level frameworks for adolescent brain development and psychopathology: dual-systems resting-state model, intrinsic connectivity, and network-level alterations across emotion and mood disorders [7], [15], [12], [2].
• Methodological and data-quality improvements enabling adolescent neuroimaging research: advanced image processing pipelines for large-scale studies and artifact correction to improve motion and physiological confounds [1], [14].